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| Document Title |
Changes in Fetal Adipose Tissue Mass in Obese Ewes
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| Type of Resource |
still image
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| Date Created |
2009-05-14
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| Digital Origin |
born digtal
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| Rights Statement |
http://digital.uwyo.edu/copyright.htm
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| Keyword (topic) |
gestational obesity
fetal adipose-deposition
sheep
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| Series Title |
Undergrauate Research Day 2009
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| Creator(s) |
Koonce, Carlie
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| Contributor(s) |
Ford, Dr. Stephen
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| Publisher |
University of Wyoming
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| Place of publication |
Laramie, Wyoming
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| Language |
eng
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| Summary |
The recent literature suggests a correlation between the maternal nutritional environment and patterns of adipose deposition in the fetus, such that pre-gravid and gestational obesity increases the likelihood of above-average fat deposition in offspring. Studies have shown that birth weight is a factor in later insulin resistance, cardiovascular disease, and obesity such that both higher- and lowerthan- average birth weights are most susceptible to the onset of metabolic disease in adult life. The purpose of this study was to investigate the patterns of fetal adipose-deposition in response to maternal nutrition in sheep as a model for human development and disease predisposition. Based on the relationship between maternal and fetal weight described in the literature, it was hypothesized that fetuses of obese ewes would be fatter than fetuses of control ewes, and as a result, would have significantly more visceral fat. This increased adiposity was expected to be demonstrated as larger adipocytes per unit area in pericardial and perirenal fat depots in fetuses of obese ewes compared to fetuses of control ewes. Fetal fat tissues were sectioned, stained, photographed, and analyzed using image software. Statistical analysis of average adipocyte size and adipocytes per unit area showed no significant difference between treatment levels.
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| Notes |
From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
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