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| Title |
Arginase and Brisket Disease in Cattle
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| Type of Resource |
still image
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| Date Created |
2009-05-13
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| Digital Origin |
born digtal
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| Rights Statement |
http://digital.uwyo.edu/copyright.htm
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| Keyword (topic) |
Brisket disease
Arginase
pulmonary hypertension
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| Series Title |
Undergrauate Research Day 2009
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| Creator(s) |
Cranford, Kimberly
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| Contributor(s) |
Stayton, Dr. Mark
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| Publisher |
University of Wyoming
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| Place of publication |
Laramie, Wyoming
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| Language |
eng
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| Summary |
Brisket disease, otherwise known as high altitude sickness and known to cause pulmonary hypertension in humans, also plays a detrimental role in the cattle industry. Though it is understood that many cattle are dying from brisket disease, a cause and treatment for the disease has not yet been fully understood or implimented. Arginase, an enzyme that plays a major role in pulmonary hypertension in humans, may also be a factor in the metabolic pathway leading to brisket disease in cattle. My experiment shows how the bovine Arginase1 gene has been isolated and cloned from cattle lung tissue. To test the association between elevated ARG1 levels and brisket disease in cattle, I have cloned the full-length coding region for bovine ARG1 into a bacterial expression vector. By this means, I have produced the bovine ARG1 in E. coli. Eventually, ARG1 will be purified and an antibody synthesized to detect the bovine ARG1 in cattle as a means to successfully identify cattle with brisket disease.
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| Notes |
From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
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