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| Document Title |
Histophilus somni myocarditis: An important cause of fatal disease in feeder cattle in Wyoming
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| Type of Resource |
still image
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| Date Created |
2009-05-12
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| Digital Origin |
born digtal
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| Rights Statement |
http://digital.uwyo.edu/copyright.htm
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| Keyword (topic) |
Septicemic Histophilosis
bovine myocarditis
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| Series Title |
Undergrauate Research Day 2009
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| Creator(s) |
Allen, Travis H.
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| Contributor(s) |
Hunter, Dr. Randy
O’Toole, Dr. Donal
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| Publisher |
University of Wyoming
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| Place of publication |
Laramie, Wyoming
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| Language |
eng
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| Summary |
A large cattle backgrounding facility in eastern Wyoming identified a recurring septicemic syndrome responsible for 42.5% of all deaths between November and January 2007. This study quantified losses during the risk period (Oct 2008 – Feb 2009), and established its basis. Whole hearts and lung samples were examined from 20 animals in which the syndrome was diagnosed clinically. Tissues were examined by bacteriology, histopathology, ultrastructure and immunohistochemistry (IHC). Septicemic H. somni infection of one or both papillary muscles in left ventricular myocardium was present in 10, based on IHC and histology, and confirmed by bacterial culture in 7. Isolates had typical antigenic profiles and virulence motifs of H. somni (Dr. L. Corbeil, UC San Diego). A gene unique to H. somni was identified which encodes an integral membrane protein HS_0311(Dr. G. Andrews, UW). The gene was cloned for use in production of antibody for the IHC procedure. Ultrastructural examination established that bacterial emboli caused acute necrosis of microvascular endothelium. Other causes of death were pyelonephritis, bacterial and viral pneumonia, and brisket disease. We conclude that septicemic histophilosis with myocarditis occurs in the United States as a major cause of mortality. The disease will be overlooked unless incised hearts are examined post-mortem.
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| Notes |
From - Undergraduate Research Day 2009 - Celebration of Research - Abstracts
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